Emergency crews are battling a blaze involving an overturned tanker truck on the U.S. 301 overpass where it joins at Interstate 95.
The S.C. Highway Patrol is reporting at least one fatality.
The collision occurred at 2:32 p.m.
The Holly Hill Police Department reports via Twitter that U.S. 301 is shut down at the site.
A sedan with extensive damage is also several yards away from the smoldering tanker truck.
This story is developing.