A roaring blaze destroyed the home at 10532 Old Number Six Highway near Vance on Monday morning.
"It was a total loss on the house," Vance Fire Chief Scott Witherell said.
Wind gusts from Tropical Storm Irma, "pushed the fire through the house,” he said.
"No one was home when we got there," Witherell said. “The fire was fully involved when we got there."
Firefighters responded to the call just after 9 a.m.
Witherell said firefighters used between 17,000 to 18,000 gallons of water and 30 to 35 gallons of foam to extinguish the blaze.
Crews left the scene around 12:30 p.m.
The four-bedroom home, situated on four acres, burned as its residents found shelter at a neighbor’s home, two houses away.
Several departments responded, including: Providence, Holly Hill, Vance, Eutawville, Santee and the Orangeburg County Fire District. Orangeburg County EMS also responded.
The cause of the fire has not yet been determined.